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'''Endorphins''' (contracted from "endogenous morphine") are endogenous opioid neuropeptides in humans and other animals. They are produced by the central nervous system and the pituitary gland. The term implies a Pharmacology|pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to a specific chemical formulation. It consists of two parts: ''endo-'' and ''-orphin''; these are short forms of the words ''endogenous'' and ''morphine,'' intended to mean "a morphine-like substance originating from within the body". The class of endorphin compounds includes α-endorphin, β-endorphin, γ-endorphin, σ-endorphin, α-neo-endorphin, and β-neo-endorphin. The principal function of endorphins is to inhibit the transmission of pain signals; they may also produce a feeling of euphoria very...
VauthorsStefano GB, Ptáček R, Kuželová H, Kream RM | title = Endogenous morphine: up-to-date review 2011 | journal = Folia Biol. (Praha) | volume = 58 | issue = 2 | pages = 49–56 | date = 2012 | pmid = 22578954 | doi = | url = http://fb.cuni.cz/file/5635/FB2012A0008.pdf | quote = Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla. ... The apparently serendipitous finding of an opiate alkaloid-sensitive, opioid peptide-insensitive, µ3 opiate receptor subtype expressed by invertebrate immunocytes, human blood monocytes, macrophage cell lines, and human blood granulocytes provided compelling validating evidence for an autonomous role of endogenous morphine as a biologically important cellular signalling molecule (Stefano et al., 1993; Cruciani et al., 1994; Stefano and Scharrer, 1994; Makman et al., 1995). ... Human white blood cells have the ability to make and release morphine}}|group="note"}}) are endogenous opioid neuropeptides in humans and other animals. They are produced by the central nervous system and the pituitary gland. The term implies a Pharmacology|pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to a specific chemical formulation. It consists of two parts: ''endo-'' and ''-orphin''; these are short forms of the words ''endogenous'' and ''morphine,'' intended to mean "a morphine-like substance originating from within the body".{{cite journal | vauthors = Goldstein A, Lowery PJ | title = Effect of the opiate antagonist naloxone on body temperature in rats | journal = Life Sciences | volume = 17 | issue = 6 | pages = 927–31 | date = September 1975 | pmid = 1195988 | doi = 10.1016/0024-3205(75)90445-2 }} The class of endorphin compounds includes α-endorphin, β-endorphin, γ-endorphin, σ-endorphin, α-neo-endorphin, and β-neo-endorphin. The principal function of endorphins is to inhibit the transmission of pain signals; they may also produce a feeling of euphoria very similar to that produced by other opioids.{{cite web|title=Is there a link between exercise and happiness?
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